A `GENE` annotation type represents the existence of a gene at the associated reference coordinates.

A `GENERIC` annotation type should be used when no other annotation type will suffice.

A `TRANSCRIPT` annotation type represents the assertion that a particular region of the reference genome may be transcribed as RNA.

A `VARIANT` annotation type.

An alignment match indicates that a sequence can be aligned to the reference without evidence of an INDEL.

The hard clip operator indicates that bases at the start/end of a read have been omitted from this alignment.

The soft clip operator indicates that bases at the start/end of a read have not been considered during alignment.

The delete operator indicates that the read contains evidence of bases being deleted from the reference.

The insert operator indicates that the read contains evidence of bases being inserted into the reference.

The pad operator indicates that there is padding in an alignment.

This operator indicates that this portion of the aligned sequence exactly matches the reference.

This operator indicates that this portion of the aligned sequence is an alignment match to the reference, but a sequence mismatch.

The skip operator indicates that this read skips a long segment of the reference, but the bases have not been deleted.

Export the data to Google BigQuery.

Includes all read groups in all imported files into a single read group set.

In most cases, this strategy yields one read group set per file.

Complete Genomics masterVarBeta format.

VCF (Variant Call Format).

By default, Variant info fields are persisted if the Variant doesn't already exist in the variantset.

This operation removes an info field from the incoming Variant and persists this info field in each of the incoming Variant's Calls.

`OTHER` should be used when no other clinical significance value will suffice.

`CNV` indicates a variation in copy number.

`DELETION` indicates a deletion.

`EFFECT_OTHER` should be used when no other Effect will suffice.

`FRAME_PRESERVING_INDEL` indicates a mutation in which a multiple of three nucleotides has been inserted or deleted, resulting in no change to the reading frame of the coding sequence.

`FRAMESHIFT` indicates a mutation in which the insertion or deletion of nucleotides resulted in a frameshift change.

`INSERTION` indicates an insertion.

`MULTIPLE_REPORTED` should be used when multiple clinical signficances are reported for a variant.

`NONSYNONYMOUS_SNP` indicates a single nucleotide polymorphism mutation that results in an amino acid change.

`SNP` indicates a single nucleotide polymorphism.

`SPLICE_SITE_DISRUPTION` indicates that this variant is found in a splice site for the associated transcript, and alters the normal splicing pattern.

`STOP_GAIN` indicates a mutation that leads to the creation of a stop codon at the variant site.

`STOP_LOSS` indicates a mutation that eliminates a stop codon at the variant site.

`STRUCTURAL` indicates a large structural variant, including chromosomal fusions, inversions, etc.

`SUBSTITUTION` indicates a block substitution of two or more nucleotides.

`SYNONYMOUS_SNP` indicates a single nucleotide polymorphism mutation that results in no amino acid change.

`TYPE_OTHER` should be used when no other Type will suffice.

An annotation describes a region of reference genome.

An annotation set is a logical grouping of annotations that share consistent type information and provenance.

A call set is a collection of variant calls, typically for one sample.

A single CIGAR operation.

A bucket over which read coverage has been precomputed.

The CreateVariantSet request.

A Dataset is a collection of genomic data.

The delete variant set request.

The read group set export request.

The variant data export request.

The variant set request.

The read group set import request.

The read group set import response.

The variant data import request.

The variant data import response.

A linear alignment can be represented by one CIGAR string.

The dataset list request.

The dataset list response.

An event that occurred during an [Operation][google.longrunning.Operation].

Metadata describing an [Operation][google.longrunning.Operation].

An abstraction for referring to a genomic position, in relation to some already known reference.

A 0-based half-open genomic coordinate range for search requests.

A read alignment describes a linear alignment of a string of DNA to a [reference sequence][google.genomics.v1.Reference], in addition to metadata about the fragment (the molecule of DNA sequenced) and the read (the bases which were read by the sequencer).

A read group is all the data that's processed the same way by the sequencer.

A read group set is a logical collection of read groups, which are collections of reads produced by a sequencer.

A reference is a canonical assembled DNA sequence, intended to act as a reference coordinate space for other genomic annotations.

ReferenceBound records an upper bound for the starting coordinate of variants in a particular reference.

A reference set is a set of references which typically comprise a reference assembly for a species, such as `GRCh38` which is representative of the human genome.

The call set search request.

The call set search response.

The read group set search request.

The read group set search response.

The read search request.

The read search response.

The search variant sets request.

The search variant sets response.

The variant search request.

The variant search response.

The stream reads request.

The stream variants request.

A transcript represents the assertion that a particular region of the reference genome may be transcribed as RNA.

A variant represents a change in DNA sequence relative to a reference sequence.

A call represents the determination of genotype with respect to a particular variant.

A variant set is a collection of call sets and variants.

Metadata describes a single piece of variant call metadata.

When an [Annotation][google.genomics.v1.Annotation] or [AnnotationSet][google.genomics.v1.AnnotationSet] is created, if `type` is not specified it will be set to `GENERIC`.

Describes the different types of CIGAR alignment operations that exist.

Operations to be performed during import on Variant info fields.